Visible-Light-Driven α-Aminoalkyl Radical-Mediated C(sp3)–C(sp) Cross-Coupling of Iodoalkanes and Alkynyl Bromides

• DOI: 10.1021/acs.orglett.2c02018
• Publication Date: 2022-07-14T12:45:43Z
• Authors: Alisha Rani Tripathy; Amit Kumar; Rizwana Rahmathul...; Avishek Kumar Jha; Veera Reddy Yatham
• Keywords: Visible spectrum; Coupling reaction

We herein report a simple protocol for metal-free cross-coupling between unactivated alkyl iodides and terminal alkynyl bromides promoted by visible light. The salient features of this transformation are the utilization an organic photocatalyst commercially available tri-n-butylamine as reductant. This couples variety iodoalkanes containing different functional groups with under mild reaction conditions to afford substituted alkynes in good yields.