Electrochemical Synthesis of Polysubstituted Oxazoles from Ketones and Acetonitrile

• DOI: 10.1021/acs.orglett.2c02252
• Publication Date: 2022-08-01T04:50:10Z
• Authors: Liang Bao; Chen Liu; Wenyi Li; Jiage Yu; Min Wang; Yunfei Zhang
• Keywords: Carbon fibers

Herein we report an electrochemical strategy for the construction of polysubstituted oxazoles from easily available ketones and acetonitrile under room temperature. The method shows high efficiency, a broad substrate scope, requires no external chemical oxidant. Mechanistic investigations suggest that reaction proceeds through Ritter-type reaction/oxidative cyclization using as reactant solvent. X-ray crystallographic analysis reveals involves attack on carbonyl carbon instead α-carbon.