Selective Fluorosulfonylation of Thianthrenium Salts Enabled by Electrochemistry

• DOI: 10.1021/acs.orglett.2c03956
• Publication Date: 2023-01-25T13:30:03Z
• Authors: Xianqiang Kong; Yiyi Chen; Qianwen Liu; WenJie Wang; Shuangquan Zhang; Qian Zhang; Xiaohui Chen; Yuan-Qing Xu; Zhong-Yan Cao
• Keywords: 01 natural sciences; 0104 chemical sciences

A practical electrochemically driven method for fluorosulfonylation of both aryl and alkyl thianthrenium salts has been disclosed. The strategy does not need external redox reagents or metal catalysts. In combination with C-H thianthrenation aromatics, this provides a new tool the site-selective drugs.