Self-Healing of a Copper(I) [2]Rotaxane Shuttle Monitored by Fluorescence

• DOI: 10.1021/acs.orglett.2c04237
• Publication Date: 2023-02-03T18:48:07Z
• Authors: Debabrata Mondal; Sohom Kundu; Emad Elramadi; Isa Valiyev; Michael Schmittel
• Keywords: Rotaxane

We demonstrate self-healing of the shuttling dynamics a molecular machine operating by negative feedback. When zinc(II) was added to copper(I)-loaded [2]rotaxane shuttle [Cu(R)]+, copper(I) replaced, thereby generating static zinc(II)-loaded [Zn(R)]2+. Loss accompanied fluorescence enhancement at λ = 364 nm. Notably, released ions catalyzed formation bis-triazole ligand, which selectively captured zinc(II). As result, restored in rotaxane, and dynamic motion [Cu(R)]+ regained. The healing conveniently followed diagnostic changes.