One-Step Synthesis of Benzophosphole Derivatives from Arylalkynes by Phosphenium-Dication-Mediated Sequential C–P/C–C Bond Forming Reaction

• DOI: 10.1021/acs.orglett.3c00263
• Publication Date: 2023-02-23T15:27:48Z
• Authors: Kazutoshi Nishimura; Shibo Xu; Yuji Nishii; Koji Hirano
• Keywords: Dication; Triple bond; Component (thermodynamics)

A metal-free, phosphenium-dication-mediated sequential C-P and C-C bond forming reaction has been developed. This protocol can provide concise access to the (di)benzophosphole derivatives in one synthetic operation from readily available simple arylalkynes phosphinic acids. Application multiple cyclization fully intermolecular three-component-coupling-type are also described.