Photoinduced Copper-Catalyzed C(sp3)–P Bond Formation by Coupling of Secondary Phosphines with N-(Acyloxy)phthalimides and N-Fluorocarboxamides

• DOI: 10.1021/acs.orglett.3c00475
• Publication Date: 2023-02-24T14:49:00Z
• Authors: Chuanyong Wang; Qiangqiang Ge; Cheng Xu; Zhongqiu Xing; Jianqi Xiong; Yu Zheng; Wei-Liang Duan
• Keywords: Phthalimides

A photoinduced copper-catalyzed C(sp3)-P bond formation has been developed by using N-(acyloxy)phthalimides as radical precursors and secondary phosphine boranes coupling partners. variety of alkyl carboxylic acid derivatives can be readily transformed into the corresponding phosphines with high reaction efficiency structural diversity. Besides, utilizing 1,5-HAT N-centered process, δ C(sp3)-H coupled phosphines, which provides a novel method for regioselective bonds.