Four-Component Ring-Opening Reaction of Pyrroles via C–N Bond Cleavage under Multiple Functions of Elemental Sulfur

• DOI: 10.1021/acs.orglett.3c00945
• Publication Date: 2023-04-23T19:50:00Z
• Authors: Zongkang Wang; Ye Wang; Yang Yuan; Yingge Gu; Yilin Zhu; Lijie Liu; Ziyi Zhuang; Lingkai Kong; Yanzhong Li
• Keywords: Thioamide; Cleavage (geology); Thiazole; Bond cleavage; Component (thermodynamics)

We report a four-component ring-opening reaction of pyrroles via C-N bond cleavage. In this process, elemental sulfur is used as the source thiazole and thioamide reductant olefin. A series benzothiazoles functionalized with thiopropionamides at C2 position were synthesized using method. plausible mechanism proposed based on concise control experiments.