Base-Promoted S-Arylation of Sulfenamides for the Synthesis of Sulfilimines

• DOI: 10.1021/acs.orglett.3c01436
• Publication Date: 2023-06-02T16:31:45Z
• Authors: Qinglong Zhou; Jiaomeng Li; Tianyi Wang; Xing Yang
• Keywords: Base (topology)

Sulfilimines are key intermediates to common motifs in medicines and agrochemicals. Typically, this class of compounds prepared by imidation thioethers, transition-metal-catalyzed or base-promoted sulfur alkylation arylation. Here, we report a practical efficient base-mediated arylation reaction for the preparation sulfilimines. A wide range N-acyl N-aryl sulfenamides react with various diaryliodonium salts smoothly afford sulfilimines high yields excellent chemoselectivities.