Photocatalytic Umpolung Strategy for the Synthesis of α-Amino Phosphine Oxides and Deuterated Derivatives

• DOI: 10.1021/acs.orglett.3c03193
• Publication Date: 2023-10-30T19:42:22Z
• Authors: Chunhua Ma; Xiaofeng Li; Xiya Chen; Xing He; Shu-Ting Zhang; Yu-Qin Jiang; Bing Yu
• Keywords: Umpolung

Direct, economical, and green synthesis of deuterated α-amino phosphine oxides remains an elusive challenge in synthetic chemistry. Herein, we report a visible-light-driven umpolung strategy for synthesizing from isocyanide using 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene as the photocatalyst D2O deuterium source. Moreover, streamlined sustainable methodology can be applied modification amino acids, natural products, drugs. The strong antiproliferative activity desired products indicates that method could provide novel privileged scaffold antitumor drug development.