Bifunctional Squaramide-Catalyzed Asymmetric Cascade Reaction of Benzothiazoles with 2-Nitroallylic Acetates or Nitroenynes

• DOI: 10.1021/acs.orglett.3c03692
• Publication Date: 2023-12-15T01:47:50Z
• Authors: Xiaoxiao Song; Wei Qin; Xuyang Wang; Gen Luo; Qijian Ni
• Keywords: Stereocenter; Squaramide; Cascade reaction

We describe here an organocatalytic asymmetric cascade formal [3 + 3] cycloaddition of benzothiazoles with 2-nitroallylic acetates and nitroenynes. This dearomative methodology provided a facile efficient strategy for the construction broad range valuable benzothiazolopyridines bearing two adjacent stereogenic centers in moderate to good yields excellent stereocontrol.