Photocatalytic Sulfonyl Peroxidation of Alkenes via Deamination of N-Sulfonyl Ketimines

• DOI: 10.1021/acs.orglett.4c00241
• Publication Date: 2024-02-22T20:47:40Z
• Authors: Yuting Feng; Shujun Chen; Leiyang Lv; Ivan A. Yaremenko; Alexander O. Tere...; Zhiping Li
• Keywords: Sulfonyl; Deamination

A photocatalytic three-component sulfonyl peroxidation of alkenes with N-sulfonyl ketimines and tert-butyl hydroperoxide is reported. The reaction takes place via the photoinduced EnT process, which allows efficient synthesis a variety β-peroxyl sulfones under mild conditions in absence transition metal catalyst. downstream derivatizations peroxides were also performed. Furthermore, utility this protocol was manifested by 11β-HSD1 inhibitor antiprostate cancer drug bicalutamide.