Photoinduced [3 + 2] Cycloadditions of Aryl Cyclopropyl Ketones with Alkynes and Alkenes
Alkene
Alkyne
DOI:
10.1021/acs.orglett.4c00843
Publication Date:
2024-04-28T16:00:02Z
AUTHORS (8)
ABSTRACT
The five-membered ring skeleton is one of the most pivotal in area pharmaceutical and natural products. [3 + 2] cycloadditions cyclopropyl unsaturated compounds are a highly efficient atom-economical way to build five-member compound. previous works about kind usually utilized metal or organic small molecule catalysts. However, an ideal cycloaddition reaction that smoothly happens without any additives catalysts under mild conditions underdeveloped. Hence, we report aryl purple LED. In this method, broad scope cyclopropyl, alkyne, alkene was very compatible, especially drug derivatives ibuprofen Ioxoprofen, obtain corresponding product with good yield up 93%.
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