Sulfonamides as N-Centered Radical Precursors for C–N Coupling Reactions To Generate Amidines

• DOI: 10.1021/acs.orglett.4c01014
• Publication Date: 2024-04-30T19:20:52Z
• Authors: Guogang Deng; Zhuo Chen; Yifeng Bai; Lening Zhang; Dazhen Xia; Shengzu Duan; Wen Chen; Hongbin Zhang; Patrick J. Walsh; Xiaodong Yang
• Keywords: Coupling reaction

Nitrogen-centered radicals (NCRs) are valuable intermediates for the construction of C-N bonds. Traditional methods generation NCRs employ toxic radical initiators, transition metal catalysts, photocatalysts, or organometallic reagents. Herein, we report a novel strategy toward bonds under transition-metal-free conditions. Thus, super-electron-donor (SED) 2-azaallyl anions undergo single-electron transfer (SET) with sulfonamides, forming aminyl (R