Access to Reverse Glycosyl Azides and Rare Sugar-Based Glycosyl Azides via Radical Decarboxylative Azidation: Divergent Synthesis of 4'-C-Azidonucleosides as Potential Antiviral Agents

• DOI: 10.1021/acs.orglett.4c01084
• Publication Date: 2024-04-30T12:52:30Z
• Authors: Qikai Sun; Jingxuan Ni; Shanshan Li; Han Ding; Peng Wang; Ni Song; Xin Wang; Ming Li

The radical decarboxylative azidation of structurally diverse uronic acids has been established as an efficient approach to reverse glycosyl azides and rare sugar-derived under the action Ag2CO3, 3-pyridinesulfonyl azide, K2S2O8. power this method highlighted by divergent synthesis 4'-C-azidonucleosides using Vorbrüggen glycosylation nucleobases with 4-C-azidofuranosyl acetates. antiviral assessment resulting nucleosides revealed one compound a potential inhibitor covalently closed circular DNA.