Aminosulfonylation of Alkenes for the Synthesis of β-Amino Sulfone Derivatives

• DOI: 10.1021/acs.orglett.4c01103
• Publication Date: 2024-05-14T19:33:41Z
• Authors: Hengyue Zhang; Xingda Zhao; Ruihan Yan; Weilong Lin
• Keywords: Homolysis; Sulfone; Functional group

β-amino sulfones are important motifs found in natural products and active pharmaceutical compounds. Herein, we report a general highly regioselective intermolecular aminosulfonylation of alkenes via the homolysis sulfinyl oximes from ketoximes chloride. This method features catalyst-free, step-efficient functionalization prominent functional group tolerance, providing straightforward, green, widely applicable approach to accessing sulfone derivatives.