Mild Strategy for the Preparation of Alkyl Sulfonyl Fluorides from Alkyl Bromides and Alcohols Using Photoredox Catalysis and Flow Chemistry

• DOI: 10.1021/acs.orglett.4c01216
• Publication Date: 2024-04-25T21:01:14Z
• Authors: Alejandro Gutiérr...; Staffan Karlsson; Daniele Leonori; Mateusz P. Plesniak
• Keywords: Sulfonyl; Photoredox catalysis; Flow chemistry

Facile access to sp3-rich scaffolds containing a sulfonyl fluoride group is still limited. Herein, we describe mild and scalable strategy for the preparation of alkyl fluorides from readily available bromides alcohols using photoredox catalysis. This approach based on halogen atom transfer (XAT), followed by SO2 capture fluorination. The method features conditions enabling fast high-value derivatives has been scaled up 5 g continuous stirred tank reactor cascade.