Stepwise Synthesis of Low-Symmetry Hexacationic Pyridinium Organic Cages

• DOI: 10.1021/acs.orglett.4c01438
• Publication Date: 2024-05-09T11:51:41Z
• Authors: Jin-Xin Wang; Shao-Chuan Li; Li-Xuan Cai; Shao-Jun Hu; Li-Peng Zhou; Jian Yang; Qing-Fu Sun
• Keywords: Cage; Linker; Triazine

An efficient approach was developed for the synthesis of well-known BlueCage by pre-bridging two 2,4,6-tris(4-pyridyl)-1,3,5-triazine (TPT) panels with one linker followed cage formation in a much improved yield and shortened reaction time. Such stepwise methodology further applied to synthesize three new pyridinium organic cages, C2, C3, C4, where low-symmetry cages C3 C4 angled demonstrated better recognition properties toward 1,1′-bi-2-naphthol (BINOL) than high-symmetry analogue C2 featuring parallel platforms.