Intramolecular Friedel–Crafts Reactions of Sulfamoyl Fluorides, Fluorosulfates, and Sulfuramidimidoyl Fluorides

• DOI: 10.1021/acs.orglett.4c04464
• Publication Date: 2025-01-31T02:04:41Z
• Authors: Taijie Guo; Long Xu; Jiajia Dong
• Keywords: Friedel–Crafts reaction

Sultams are valuable heterocycles with numerous applications, particularly as pharmacophores. Previous syntheses of these compounds usually require metal-catalyzed cyclization or multiple-step processes. Here, we report a straightforward strategy for accessing important motifs by developing the intramolecular Friedel-Crafts sulfamoyl fluorides under mild conditions. Our protocol also accommodates fluorosulfates and sulfuramidimidoyl fluorides, which rarely utilized in reactions.