Dearomative Alkylation of Heteroarenium Salts via Blue Light Enabled Homolytic C–C Bond Cleavage

• DOI: 10.1021/acs.orglett.4c04831
• Publication Date: 2025-02-06T01:01:26Z
• Authors: Agshin Garayev; Emma E. Drake; Evangelos Miliordos; Rashad R. Karimov
• Keywords: Homolysis; Bond cleavage; Cleavage (geology)

Alkyl substituted nitrogen heterocycles are important building blocks in drug molecules, agrochemicals, and materials. Herein we report a simple efficient way to prepare such compounds by coupling alkyl halides with heteroarenium salts. Detailed experimental computational studies indicate that this reaction goes through radical avoids the formation of undesired homocoupling salts via recycling dimers C–C bond cleavage under blue light.