Enantioselective Direct Functionalization of Indoles by Pd/Sulfoxide-Phosphine-Catalyzed N-Allylic Alkylation

• DOI: 10.1021/acs.orglett.5b00077
• Publication Date: 2015-03-04T18:18:52Z
• Authors: Li-Yan Chen; Xiao-Ye Yu; Jia-Rong Chen; Bin Feng; Hong Zhang; Ying-Hua Qi; Wen-Jing Xiao
• Keywords: Tsuji–Trost reaction; Sulfoxide; Surface Modification

A general and efficient Pd/sulfoxide-phosphine complex-catalyzed direct asymmetric N-allylic alkylation of indoles has been developed to allow for the preparation various N-allylated in generally good yields with excellent enantioselectivities. This catalytic system could also be extended other N-containing heterocycles results.