Organocatalytic Atroposelective Formal Diels–Alder Desymmetrization of N-Arylmaleimides

• DOI: 10.1021/acs.orglett.5b00509
• Publication Date: 2015-03-17T11:41:23Z
• Authors: Florine Eudier; Paolo Righi; Andrea Mazzanti; Alessia Ciogli; Giorgio Bencivenni
• Keywords: Desymmetrization; Bridged compounds; Diels–Alder reaction

The atroposelective desymmetrization of N-arylmaleimides was realized by means a primary amine catalyzed Diels-Alder reaction enones. chiral axis as new element chirality is generated under the remote control catalyst that selectively drives formal through an exclusive stereochemical outcome.