Silver-Catalyzed Tandem Hydroazidation/Alkyne–Azide Cycloaddition of Diynes with TMS-N3: An Easy Access to 1,5-Fused 1,2,3-Triazole Frameworks

• DOI: 10.1021/acs.orglett.5b00784
• Publication Date: 2015-04-20T17:37:00Z
• Authors: Yongquan Ning; Nannan Wu; Haifeng Yu; Peiqiu Liao; Xingqi Li; Xihe Bi
• Keywords: Alkyne; Tandem; Triazole

A general cascade hydroazidation and alkyne-azide 1,3-dipolar cycloaddition of diynes using silver catalysis is reported. wide variety participated in the reaction with trimethylsilyl azide (TMS-N3) presence H2O, affording corresponding 1,5-fused-1,2,3-triazoles good-to-excellent yields. This unprecedented protocol operationally simple a broad substrate scope, good functional group tolerance, high efficiency, thus providing easy access to various fused 1,2,3-triazoles.