Asymmetric Synthesis of α-Amino Ketones by Brønsted Acid Catalysis

• DOI: 10.1021/acs.orglett.5b01972
• Publication Date: 2015-07-28T13:34:38Z
• Authors: Wei Wen; Yu Zeng; Li-Yu Peng; Li-Na Fu; Qi-Xiang Guo
• Keywords: Brønsted–Lowry acid–base theory; Reductive amination; Transfer hydrogenation

The highly efficient, regioselective, and enantioselective transfer hydrogenation of α-keto ketimines reductive amination diketones by Brønsted acid catalysis is described. A series chiral α-amino ketones prepared in high yields (up to >99%), excellent regioselectivities >99:1), enantioselectivities 98% ee). This method has broad substrate scope.