Rhodium(III)-Catalyzed C–H Activation/Alkyne Annulation by Weak Coordination of Peresters with O–O Bond as an Internal Oxidant

• DOI: 10.1021/acs.orglett.5b02291
• Publication Date: 2015-09-28T14:21:17Z
• Authors: Jiayu Mo; Lianhui Wang; Xiuling Cui
• Keywords: Annulation; Oxidizing agent; Alkyne; Bond cleavage; Functional group

A redox-economic strategy has been developed, involved in an efficient Rh(III)-catalyzed oxidative C–H activation and alkyne annulation with perester as the oxidizing directing group. In this process, cleavage of O–O bond internal oxidant is described for first time. This reaction could be carried out under mild conditions exhibits excellent regioselectivity wide functional groups tolerance.