Syn-Selective Synthesis of β-Branched α-Amino Acids by Alkylation of Glycine-Derived Imines with Secondary Sulfonates

• DOI: 10.1021/acs.orglett.5b02448
• Publication Date: 2015-10-07T13:52:28Z
• Authors: Sha Lou; Grace M. McKenna; Steven A. Tymonko; Antonio Ramirez; Tamas Benkovics; David A. Conlon; Francisco Gonzále...
• Keywords: Alkylation; Molecular Structure; Carboxylic Acids; Glycine; Esters; Stereoisomerism; 01 natural sciences; Catalysis; 3. Good health; 0104 chemical sciences; 13. Climate action; Imines; Amino Acids; Sulfonic Acids

AbstractThe utility of the method is demonstrated by the synthesis of the pharmaceutically relevant glutamic acid derivative (VII) as well as the kilogram‐scale preparation of (VIII).