Syn-Selective Synthesis of β-Branched α-Amino Acids by Alkylation of Glycine-Derived Imines with Secondary Sulfonates
Imine
Protecting group
DOI:
10.1021/acs.orglett.5b02448
Publication Date:
2015-10-07T13:52:28Z
AUTHORS (7)
ABSTRACT
A syn-selective synthesis of β-branched α-amino acids has been developed based on the alkylation glycine imine esters with secondary sulfonates. The potassium counterion for enolate, solvent, and leaving group electrophile were key levers to maximize diasteroselectivity alkylation. optimized conditions enabled a straightforward preparation number that can be challenging obtain.
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