Syn-Selective Synthesis of β-Branched α-Amino Acids by Alkylation of Glycine-Derived Imines with Secondary Sulfonates

Imine Protecting group
DOI: 10.1021/acs.orglett.5b02448 Publication Date: 2015-10-07T13:52:28Z
ABSTRACT
A syn-selective synthesis of β-branched α-amino acids has been developed based on the alkylation glycine imine esters with secondary sulfonates. The potassium counterion for enolate, solvent, and leaving group electrophile were key levers to maximize diasteroselectivity alkylation. optimized conditions enabled a straightforward preparation number that can be challenging obtain.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (43)
CITATIONS (12)