Palladium-Catalyzed Intermolecular 1,3-Dienylation of Propargyl Esters Involving the Insertion of SO2

• DOI: 10.1021/acs.orglett.5c00334
• Publication Date: 2025-02-21T01:59:42Z
• Authors: Haohao Jiang; Mengzhao Yu; Shuoshuo Zhang; Ling Jin; Yue Zhang; Xiaolei Huang
• Keywords: Propargyl

A palladium-catalyzed three-component 1,3-dienylation of propargylic esters with DABSO and aryl iodides has been developed. This novel reductive cross-coupling reaction produces 2-sufonylated 1,3-dienes as single products in the presence metal Mn high regio- chemoselectivities. Control experiments demonstrated that transformation may undergo a radical process.