Rhodium-Catalyzed/Copper-Mediated Tandem C(sp2)–H Alkynylation and Annulation: Synthesis of 11-Acylated Imidazo[1,2-a:3,4-a′]dipyridin-5-ium-4-olates from 2H-[1,2′-Bipyridin]-2-ones and Propargyl Alcohols

• DOI: 10.1021/acs.orglett.6b00177
• Publication Date: 2016-02-16T12:33:58Z
• Authors: Ting Li; Zhiqiang Wang; Kun Xu; Wenmin Liu; Xu Zhang; Wutao Mao; Yongming Guo; Xiaolin Ge; Fei Pan
• Keywords: Annulation; Alkynylation; Tandem

A rhodium-catalyzed/copper-mediated tandem C(sp2)–H alkynylation and intramolecular annulation of 2H-[1,2′-bipyridin]-2-ones with propargyl alcohols for the synthesis 11-acylated imidazo[1,2-a:3,4-a′]dipyridin-5-ium-4-olates is described.