Synthesis of the C1–C10 Fragment of Madeirolide A

• DOI: 10.1021/acs.orglett.6b00777
• Publication Date: 2016-04-14T16:04:44Z
• Authors: Sunghyun Hwang; Inhwan Baek; Chulbom Lee
• Keywords: Fragment (logic); Stereospecificity

The synthesis of a fully elaborated C1–C10 fragment madeirolide A has been achieved via strategy based on series stereospecific processes. concise synthetic route also features an iridium-catalyzed visible light induced radical cyclization for construction the THP ring and palladium-catalyzed glycosylation formation α-cineruloside linkage.