Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa

• DOI: 10.1021/acs.orglett.6b00979
• Publication Date: 2016-05-13T20:01:35Z
• Authors: Jacqueline L. von...; Christopher G. Wi...; Renee M. Fleeman; James B. McClintock; Charles D. Amsler; Lindsey N. Shaw; Bill J. Baker
• Keywords: Methicillin-Resistant Staphylococcus aureus; Molecular Structure; Antarctic Regions; Microbial Sensitivity Tests; 01 natural sciences; Anti-Bacterial Agents; Cell Line; Porifera; 0104 chemical sciences; 3. Good health; Inhibitory Concentration 50; Mice; Biofilms; Animals; Diterpenes

AbstractDarwinolide (I) shows cytotoxic activity.