Palladium(II)-Catalyzed Cross-Dehydrogenative Coupling (CDC) of N-Phthaloyl Dehydroalanine Esters with Simple Arenes: Stereoselective Synthesis of Z-Dehydrophenylalanine Derivatives

• DOI: 10.1021/acs.orglett.6b01255
• Publication Date: 2016-05-21T23:53:30Z
• Authors: Francesca Bartoccini; Diego Maria Cannas; Francesco Fini; Giovanni Piersanti
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractThe title reaction involves the cleavage of two sp2 C—H bonds followed by C—C bond formation, generating (Z)‐dehydrophenylalanine skeletons in a stereoselective and atom economical manner.