Time Economical Total Synthesis of (−)-Oseltamivir

• DOI: 10.1021/acs.orglett.6b01595
• Publication Date: 2016-07-05T13:02:42Z
• Authors: Yujiro Hayashi; Shin Ogasawara
• Keywords: Oseltamivir

A time economical 60 min total synthesis of (−)-oseltamivir was accomplished in a single reaction vessel over five steps. One the key issues is reduction number steps by eliminating lengthy with substitution rapid epimerization step. catalytic system consisting three reagents, namely, diphenylprolinol silyl ether, thiourea, and acid, developed for asymmetric Michael excellent diastereo- enantioselectivities. All reactions were optimized terms not only yield selectivity but also time.