Expanding the Scope of the Gold(I)-Catalyzed Rautenstrauch Rearrangement: Protic Additives

• DOI: 10.1021/acs.orglett.6b02505
• Publication Date: 2016-09-23T17:17:45Z
• Authors: Cédric Bürki; Andrew Whyte; Sebastian Arndt; A. Stephen K. Hashmi; Mark Lautens
• Keywords: 01 natural sciences; 0104 chemical sciences

The synthesis of substituted 2-cyclopentenones using a commercially available gold(I) catalyst is described under flexible reaction conditions. During the course of our investigations, we discovered that using a proton source as an additive is required to obtain the desired substituted cyclopentenones in good yields.