Total Synthesis of Nannocystin A

• DOI: 10.1021/acs.orglett.6b02729
• Publication Date: 2016-10-13T17:15:35Z
• Authors: Zhantao Yang; Xiaolong Xu; Chun-Hua Yang; Yunfeng Tian; Xinyi Chen; Lihui Lian; Wenwei Pan; Xuncheng Su; Weicheng Zhang; Yue Chen
• Keywords: Macrocyclic Compounds; Cyclization; Molecular Conformation; 01 natural sciences; 0104 chemical sciences

Nannocystin A is a 21-membered cyclodepsipeptide showing remarkable anticancer properties. Described is the total synthesis of nannocystin A, which features an asymmetric vinylogous Mukaiyama aldol reaction for efficient assembly of the penultimate open-chain precursor and a pivotal intramolecular Heck cross-coupling for the final macrocyclization.