Asymmetric Induction in Hydroacylation by Cooperative Iminium Ion–Transition-Metal Catalysis

• DOI: 10.1021/acs.orglett.6b02825
• Publication Date: 2016-10-21T16:04:40Z
• Authors: Ettore J. Rastelli; Ngoc T. Truong; Don M. Coltart
• Keywords: Hydroacylation; Iminium; Asymmetric induction

A new strategy for the rhodium-catalyzed enantioselective hydroacylation is described. This has been achieved through merger of iminium ion catalysis and transition-metal such that asymmetric induction derives from a readily accessible, inexpensive chiral nonracemic secondary amine catalyst rather than phosphine as typical conventional methods.