Garmultins A–G, Biogenetically Related Polycyclic Acylphloroglucinols from Garcinia multiflora

Undecane Decane
DOI: 10.1021/acs.orglett.6b03004 Publication Date: 2016-11-10T11:22:35Z
ABSTRACT
Garmultins A and B (1 2), two polycyclic polyprenylated acylphloroglucinols characterized by the coupling of novel cages, 2,11-dioxatricyclo[4.4.1.03,9]undecane tricyclo[4.3.1.03,7]decane, along with five biogenetically related analogues (3-7), were isolated from Garcinia multiflora. Their structures absolute configurations determined extensive NMR analysis, X-ray crystallography, electronic circular dichroism calculations. Three compounds capable inhibiting oncogene expression inducing apoptosis in human erythroleukemia cells.
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