Garmultins A–G, Biogenetically Related Polycyclic Acylphloroglucinols from Garcinia multiflora

• DOI: 10.1021/acs.orglett.6b03004
• Publication Date: 2016-11-10T11:22:35Z
• Authors: Dong Song Tian; Ping Yi; Lei Xia; Xin Xiao; Yi Min Fan; Wei Gu; Lie Jun Huang; Yaacov Ben-David; Ying Tong Di; Chun Mao Yuan; Xiao Jiang Hao
• Keywords: Molecular Structure; Cell Survival; Acylation; HL-60 Cells; Phloroglucinol; Antineoplastic Agents, Phytogenic; 01 natural sciences; 0104 chemical sciences; A549 Cells; MCF-7 Cells; Humans; Polycyclic Aromatic Hydrocarbons; Garcinia

Garmultins A and B (1 and 2), two polycyclic polyprenylated acylphloroglucinols characterized by the coupling of two novel cages, 2,11-dioxatricyclo[4.4.1.03,9]undecane and tricyclo[4.3.1.03,7]decane, along with five biogenetically related analogues (3-7), were isolated from Garcinia multiflora. Their structures and absolute configurations were determined by extensive NMR analysis, X-ray crystallography, and electronic circular dichroism calculations. Three compounds were capable of inhibiting oncogene expression and inducing apoptosis in human erythroleukemia cells.