Synthesis of Polycarbonyl Pyrroles via K2S2O8-Mediated Oxidative Cyclization of Enamines

• DOI: 10.1021/acs.orglett.6b03060
• Publication Date: 2016-11-15T20:26:42Z
• Authors: Peng Gao; Juan Wang; Zi-Jing Bai; Li Shen; Yun-Yun Yan; De-Suo Yang; Ming-Jin Fan; Zheng-Hui Guan
• Keywords: Scope (computer science)

A novel K2S2O8-promoted oxidative cyclization of enamines is described. variety having diverse functional groups and substitution patterns react well using K2S2O8 as the oxidant in absence catalyst. This protocol provides a very simple route for synthesis polycarbonyl pyrroles has advantages readily available starting materials, mild reaction conditions, wide scope substrates.