IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with α-Galactosylceramide as Built-in Adjuvant

• DOI: 10.1021/acs.orglett.6b03591
• Publication Date: 2017-01-25T19:55:32Z
• Authors: Xu-Guang Yin; Xiang-Zhao Chen; Wen-Mei Sun; Xiao-Shan Geng; Xiao-Kang Zhang; Jian Wang; Pan-Pan Ji; Zhong-Yin Zhou; Dong Jae Baek; Guang-Fu Yang; Zheng Liu; Jun Guo
• Keywords: Antibody response

A fully synthetic self-adjuvanting cancer vaccine candidate was constructed through covalent conjugation of invariant natural killer T (iNKT) cell ligand α-galactosylceramide (αGalCer) with sialyl Tn (STn), a representative tumor-associated carbohydrate antigen (TACA). This two-component STn-αGalCer is devoid antigenic peptide, featuring the well-defined structure high simplicity. showed remarkable efficacy in inducing antibody class switching from IgM to STn-specific IgG. Subtypes IgG were primarily IgG1 and IgG3.