Silver-Mediated Oxidative Decarboxylative Trifluoromethylthiolation of Coumarin-3-carboxylic Acids

• DOI: 10.1021/acs.orglett.6b03806
• Publication Date: 2017-01-23T13:16:59Z
• Authors: Minghao Li; Jeffrey L. Petersen; Jessica M. Hoover
• Keywords: 01 natural sciences; 0104 chemical sciences

The introduction of trifluoromethylthio groups into organic compounds, in particular heterocycles, is important because the prevalence these structures medicinally and agriculturally relevant molecules. Herein, silver-mediated oxidative decarboxylative trifluoromethylthiolation coumarin-3-carboxylic acids reported. This methodology utilizes existing carboxylic acid functionalities for direct conversion to CF3S results a broad scope 3-trifluoromethylthiolated coumarins, including analogues natural products, moderate excellent yields.