Copper-Catalyzed Stereodefined Construction of Acrylic Acid Derivatives from Terminal Alkynes via CO2 Insertion

• DOI: 10.1021/acs.orglett.6b03860
• Publication Date: 2017-02-08T21:48:13Z
• Authors: Kenta Kuge; Ying Luo; Yuki Fujita; Yasuyuki Mori; Gen Onodera; Masanari Kimura
• Keywords: 01 natural sciences; 0104 chemical sciences

IPrCuCl catalyzes the CO2 insertion reaction undergone by a dialkylvinylborane intermediate derived from alkynyltrialkylborate by a 1,2-alkyl group migration to afford α-alkyl acrylic acids with excellent regio- and stereoselectivities.