Versicoamides F–H, Prenylated Indole Alkaloids from Aspergillus tennesseensis

• DOI: 10.1021/acs.orglett.7b00145
• Publication Date: 2017-02-09T14:30:19Z
• Authors: Li Liu; Long Wang; Li Bao; Jinwei Ren; Buddha Bahadur Ba...; Ruixing Liu; Luwei He; Junjie Han; Wen-Bing Yin; Hongwei Liu
• Keywords: Prenylation; Molecular Structure; Cell Survival; Antineoplastic Agents; 01 natural sciences; Indole Alkaloids; 0104 chemical sciences; Aspergillus; Cell Line, Tumor; Humans; Cell Proliferation; Signal Transduction

Three highly modified indole alkaloids, versicoamides F-H (1-3), together with seven known alkaloids (4-10) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were determined by analysis of the NMR and MS spectroscopic data. The absolute configurations of 1 and 2 were assigned by single-crystal X-ray diffraction experiments. Compounds 1 and 2 showed weak antiproliferative activity against the H460 cell line. Compounds 1-3 represent a new class of natural product hybrids with new chemical skeletons.