Ag-Initiated gem-Difluoromethylenation of the Nitrogen Center of Arenediazonium Salts to gem-Difluoromethylene Azo Compounds

• DOI: 10.1021/acs.orglett.7b00936
• Publication Date: 2017-04-21T20:08:41Z
• Authors: Haizhen Jiang; Yunrong Chen; Bo Chen; Hui Xu; Wen Wan; Hongmei Deng; Kesen Ma; Shaoxiong Wu; Jian Hao
• Keywords: 01 natural sciences; 0104 chemical sciences

An efficient method for the synthesis of the thermally stable and pharmaceutically important gem-difluoromethylene azo compounds is developed. This protocol achieved gem-difluoromethylenation of the nitrogen center of arenediazonium salts through in situ generated benzo-1,3-diazolic difluoromethylene radical addition to arenediazonium salts under mild Ag-initiated conditions.