Biomimetic-Inspired Syntheses of Myrtucommuacetalone and Myrtucommulone J

• DOI: 10.1021/acs.orglett.7b02159
• Publication Date: 2017-08-25T18:46:42Z
• Authors: Hongxin Liu; Luqiong Huo; Bao Yang; Yunfei Yuan; Weimin Zhang; Zhifang Xu; Shengxiang Qiu; Haibo Tan
• Keywords: 01 natural sciences; 0104 chemical sciences; 3. Good health

Driven by bioinspiration and appreciation of their structures, the first biomimetic total syntheses with structural revision of the acylphloroglucinols myrtucommulone J and myrtucommuacetalone, two biologically meaningful natural products, were achieved through a biosynthetic hemiacetalization/dehydration/[3 + 3]-type cycloaddition domino sequence with high step efficiency. These syntheses result in a corrected structure for myrtucommulone J.