Tandem [3 + 2] Cycloaddition/1,4-Addition Reaction of Azomethine Ylides and Aza-o-quinone Methides for Asymmetric Synthesis of Imidazolidines

• DOI: 10.1021/acs.orglett.7b02512
• Publication Date: 2017-09-12T18:13:07Z
• Authors: Hao Jia; Honglei Liu; Zhenyan Guo; Jiaxing Huang; Hongchao Guo
• Keywords: Azomethine ylide; Tandem; Imidazolidine; Reaction conditions; Ylide

An enantioselective synthesis of biologically important imidazolidines has been achieved via a tandem [3 + 2] cycloaddition/1,4-addition reaction azomethine ylide and aza-o-quinone methides. With the use this tool, various imidazolidine derivatives are obtained in good yields with excellent diastereoselectivities enantioselectivities.