Palladium-Catalyzed Asymmetric Allylic Alkylation of Alkyl-Substituted Allyl Reagents with Acyclic Amides

• DOI: 10.1021/acs.orglett.7b02927
• Publication Date: 2017-10-18T14:55:52Z
• Authors: Yang-Jie Jiang; Gao-Peng Zhang; Jian-Qiang Huang; Di Chen; Chang-Hua Ding; Xue-Long Hou
• Keywords: 01 natural sciences; 0104 chemical sciences

A wide range of alkyl-substituted allyl reagents, as well as nonstabilized carbon nucleophiles, was successfully used for the first time in the palladium-catalyzed asymmetric allylic alkylation reaction, affording the corresponding allylic alkylated products in high yields with high enantioselectivities. The usefulness of the protocol has been demonstrated by the enantioselective synthesis of an important chiral building block and enantiomer of Dubiusamine A.