Determination of Taichunamide H and Structural Revision of Taichunamide A

• DOI: 10.1021/acs.orglett.8b00061
• Publication Date: 2018-02-05T13:53:16Z
• Authors: Feng Li; Zhenzhen Zhang; Guojian Zhang; Qian Che; Tianjiao Zhu; Qianqun Gu; Dehai Li
• Keywords: Moiety; Azetidine; Pyrrole; Diastereomer; Imine; Aspergillus versicolor

A new indole alkaloid, named taichunamide H (1), was obtained from cultures of the fungus Aspergillus versicolor. With observation a carbon resonance with chemical shift 190.4 ppm, generally thought to be carbonyl, structure 1 initially proposed diastereomer that contains unique spiro-azetidine moiety. Further analysis compound using X-ray diffraction showed moiety should revised as fused-imine-containing pyrrole ring, at ppm assigned an imine carbon. Accordingly, also revised.