Enantioselective and Diastereoselective Ir-Catalyzed Hydrogenation of α-Substituted β-Ketoesters via Dynamic Kinetic Resolution

• DOI: 10.1021/acs.orglett.8b00433
• Publication Date: 2018-03-20T12:56:30Z
• Authors: Guoxian Gu; Jiaxiang Lu; Ouran Yu; Jialin Wen; Qin Yin; Xumu Zhang
• Keywords: Kinetic resolution; Enantiomeric excess; Asymmetric hydrogenation

An iridium/f-amphol catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti products were obtained in high yields (up to 98%) with good diastereoselectivity 96:4 diastereometic ratio (dr)) and excellent enantioselectivity >99% enantiomeric excess (ee)). A model proposed explain stereoselectivity.