Pepluanols C–D, Two Diterpenoids with Two Skeletons from Euphorbia peplus

• DOI: 10.1021/acs.orglett.8b01114
• Publication Date: 2018-05-02T13:12:09Z
• Authors: Luo-Sheng Wan; Yin Nian; Xing-Rong Peng; Li-Dong Shao; Xiao-Nian Li; Jian Yang; Ming Zhou; Ming-Hua Qiu
• Keywords: Molecular Structure; Euphorbia; Diterpenes; Crystallography, X-Ray; 01 natural sciences; Drugs, Chinese Herbal; 0104 chemical sciences

Pepluanols C and D (1 and 2), featuring unprecedented 5/5/10 with out,out-[7.2.1]bicylcododecane core and 6/6/7/3 fused-ring skeletons, respectively, were isolated from Euphorbia peplus. Their chemical structures and absolute configurations were determined by a series of extensive spectroscopic methods, and X-ray diffraction analysis. In addition, pepluanols C and D showed 31.6 ± 8.3% and 30.5 ± 2.8% peak current inhibition on the Kv1.3 potassium channel at 30 μM.