Aureochaeglobosins A–C, Three [4 + 2] Adducts of Chaetoglobosin and Aureonitol Derivatives from Chaetomium globosum

• DOI: 10.1021/acs.orglett.8b01243
• Publication Date: 2018-05-17T19:23:11Z
• Authors: Ming-Hua Yang; Mei-Ling Gu; Chao Han; Xiao-Jiang Guo; Guo-Ping Yin; Pei Yu; Ling-Yi Kong
• Keywords: Chaetomium globosum; Chaetomium

Aureochaeglobosins A-C (1-3), three novel [4 + 2] cycloaddition heterodimers of chaetoglobosin and aureonitol derivatives, were obtained from the culture endophytic fungus Chaetomium globosum, representing first adduct examples chaetoglobosins. Their structures elucidated by extensive spectroscopic analyses, single-crystal X-ray diffraction, a modified Mosher's method. Compounds 2 3 showed significant cytotoxicities against human MDA-MB-231 cancer cells with IC50 values 7.6 10.8 μM, respectively.