K2S2O8/TEMPO-Induced Cascade Oxidative Cyclization/1,2-Migration of Electron-Deficient Groups: Strategy for the Construction of 1H-Pyrrol-2(3H)-ones

• DOI: 10.1021/acs.orglett.8b01402
• Publication Date: 2018-06-04T16:35:22Z
• Authors: Peng Gao; Juan Wang; Zijing Bai; Ming-Jin Fan; De-Suo Yang; Zheng-Hui Guan
• Keywords: 01 natural sciences; 0104 chemical sciences

A K2S2O8/TEMPO-induced oxidative cyclization of N-unprotected enaminoesters and enaminones that gave 1H-pyrrol-2(3H)-ones in good yields with broad functional group compatibility is reported. This method provides easy access to 1,2-carbon migration ester or acyl under transition-metal-free conditions.