Diboron-Catalyzed Dehydrative Amidation of Aromatic Carboxylic Acids with Amines

• DOI: 10.1021/acs.orglett.8b01480
• Publication Date: 2018-07-19T06:08:26Z
• Authors: Dinesh N. Sawant; Dattatraya B. Bagal; Saeko Ogawa; Kaliyamoorthy Selvam; Susumu Saito
• Keywords: Stoichiometry

Tetrakis(dimethylamido)diboron and tetrahydroxydiboron are herein reported as new catalysts for the synthesis of aryl amides by catalytic condensation aromatic carboxylic acids with amines. The developed protocol is both simple highly efficient over a broad range substrates. This method thus represents an attractive approach use diboron in without having to resort stoichiometric or additional dehydrating agents.